学术活动

Speaker

Christopher Bailey-Kellogg, Professor, Department of Computer Science, Dartmouth College

Time

2017.03.22 16:15-17:30

Venue

601 Pao Yue-Kong Library

Abstract

The protein universe manifests a wide array of functions that may be useful in treating disease. Unfortunately, the human immune system can recognize non-“self” proteins and mount a response decreasing therapeutic efficacy or potentially even producing harmful side effects. To meet this challenge, we have developed a computationally-driven approach that combines models of immunogenicity with models of protein stability and function, optimizing mutagenic variants so as to maintain therapeutic activity while reducing immunogenicity. This talk describes our protein design methodology and presents experimental results from application to therapeutic candidates including lysostaphin, a highly potent but immunogenic anti-staphylococcal enzyme. In contrast to wild-type lysostaphin, our variants maintain low antibody titers and are able to repeatedly rescue humanized mice from challenges with methicillin resistant Staphylococcus aureus (MRSA). This work provides the first controlled demonstration that depletion of T cell epitopes from a biotherapeutic agent leads to a reduced antibody response and consequently enhanced efficacy in an immune competent disease model.

Bio

Dr. Chris Bailey-Kellogg is Professor of Computer Science at Dartmouth College, where he is also an adjunct Professor of Chemistry. His lab develops and applies computational methods for experiment optimization and analysis in studies of protein sequence-structure-function relationships. He is currently pursuing computationally-driven development of both protein therapeutics, redesigning non-human proteins so as to render them acceptable to the immune system, as well as vaccines, modeling and engineering immune responses to infection and vaccination. Chris earned a BS/MS with Dr. Sandy Pentland at MIT and a PhD with Dr. Feng Zhao (currently serves as CTO and SVP of Haier) at Ohio State and Xerox PARC, conducted postdoctoral research with Dr. Bruce Donald at Dartmouth College, and started his faculty career at Purdue. Dr. Bailey-Kellogg has published over 70 journal articles, along with numerous refereed conference papers, at the interface of computational and life sciences. He has received a prestigious NSF Career award and Alfred P. Sloan Research Fellowship, along with more than $13 million in grants from the NIH, NSF, and Gates Foundation.

关于ZY-INS沙龙

时间:
每周三下午
地点:
致远学院601报告厅(包玉刚图书馆6楼)
形式:
主题演讲+自由交流,提供美味点心与茶水

致远学院作为我校基础学科拔尖学生培养试验基地,旨在培养引领未来的科技领袖,目前已有数学、物理、生命科学、计算机科学、化学、生物医学及工科500余名学生;自然科学研究院作为我校基础研究的交叉创新平台,旨在根本性提升交大的基础研究水平,目前已从海外引进30余名学者。两院共享位于思源湖畔的风景如画的物理空间,自然科学研究院的学者也已经成为致远学院创新型和国际化人才培养有力的师资来源。

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